Critically elucidating the role of selenium

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Regarding selenium status, only erythrocyte selenium concentration was lower in patients who died in the ICU.The frequencies for GPx1 Pro198Leu polymorphism were 55%, 38% and 7% for Pro/Pro, Pro/Leu and Leu/Leu, respectively.At the time of the patients' enrollment, demographic information was recorded.Blood samples were taken within the first 72 hours of the patients' admission or within 72 hours of the septic shock diagnosis for determination of selenium status, protein carbonyl concentration, GPx1 activity and GPx1 Pro198Leu polymorphism (rs 1050450) genotyping.This cookie stores just a session ID; no other information is captured.Accepting the NEJM cookie is necessary to use the website.

Se supplementation in septic patients have yielded conflicting results.Therefore, the objective of this study was to evaluate the association of erythrocyte selenium concentration with glutathione peroxidase (GPx1) activity, GPx1 polymorphisms and with ICU and hospital mortality in septic shock patients.METHODS: This prospective study included all patients older than 18 years with septic shock on admission or during their ICU stay, admitted to one of the three ICUs of our institution, from January to August 2012.INTRODUCTION: Selenoenzymes can modulate the extent of oxidative stress, which is recognized as a key feature of septic shock.The pathophysiologic role of erythrocyte selenium concentration in patients with septic shock remains unknown.

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